By Dr. med. Sabine Enenkel, Professor Dr. Wolfgang Stille (auth.)
International textbooks on infectious ailments and antibacterial chemotherapy tend to be written for readers in North the United States and Europe. in lots of methods, they don't seem to be applicable for the prob lems encountered in constructing international locations. This booklet, by contrast, intends to outline the foundations of antibacterial chemotherapy practised below stipulations of restricted assets. it really is intended for everybody con cerned with using antibiotics in constructing nations, includ ing medical professionals, scientific assistants, pharmacists, officers in future health mio isteries, and clinical scholars. during the publication, therapy options are made for 1 antibiotics from the WHO record of crucial medicinal drugs. for instance, em phasis has hence been placed upon chloramphenicol as a solid, unexpensive and generally on hand oral agent appropriate for the deal with ment of critical bacterial infections like septicemia and meningitis. So-called "international chemotherapy" with modem cephalospor ins and acylaminopenicillins has been defined for comparability. because it is the purpose of the publication to base remedy recommenda tions on facts from constructing international locations, many information at the etiology of universal bacterial infections in constructing international locations have additionally been incorporated. many of the information are from African, English-speak ing constructing international locations, yet references were made to the lit erature on South East Asia, India or Papua New Guinea, the place applicable. nonetheless, pertinent facts weren't to be had in each example, in order that a number of statements and suggestions needed to be made as "best guess". The authors are conscious of those imperfections and may welcome reviews from the readers.
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Additional info for Antibiotics in the Tropics: Antibacterial Therapy with Limited Resources
Dosage. Adult dose: 1-2 g as two very slow infusions. 125 g every 6-8 h in enterocolitis). Main Indications. Severe staphylococcal infections (septicemia, endocarditis, osteomyelitis), mainly by methicillin-resistant strains. Very active in pseudomembranous enterocolitis due to Clostridium difficile. Side Effects. Frequent vascular reactions (flush and hypotension due to rapid infusion). Real allergic reactions (rash, urticaria) may occur. Ototoxicity mainly in renal insufficiency. Clindamycin Clindamycin is an improved derivative of lincomycin with higher activity and better absorption.
With most other antibiotics, however, side effects regularly occur when the maximum recommended dosage is exceeded. A moderate dose is generally sufficient for less severe infections or when the causative organism is very sensitive, in which case the risk of dose-related side effects is less. If the infection does not respond, the dose can be increased up to the maximum recommended. With some antibiotics such as the tetracyclines, however, increasing the oral dose does not result in proportionately higher blood concentrations because gastrointestinal absorption is already taking place at the maximal rate.
Bull WHO 61: 661-669 9. Fall M, Kuakuvi N, Castets M, Diadhiou F, Martin L (1976) Infections neo-natales a Serratia marcescens. Bull Soc Med Afr Noire Lang Franc 21: 57-64 10. Farrar WE (1985) Antibiotic resistance in developing countries. J Infect Dis 152: 1103-1106 11. Gratten M, Naraqi S, Hansman D (1980) High prevalence of penicillin-insensitive pneumococci in Port Moresby, Papua New Guinea. Lancet II: 192-195 12. Gedebou M, Tassew A, Azene G (1984) Blood culture isolates from an Addis Abeba hospital frequency and antibiotic sensitivities.
Antibiotics in the Tropics: Antibacterial Therapy with Limited Resources by Dr. med. Sabine Enenkel, Professor Dr. Wolfgang Stille (auth.)