By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)
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Additional resources for Allergy
In the future, genetic discoveries in allergic disease will potentially lead to better endophenotyping, prognostication, prediction of treatment response, and insights into molecular pathways in order to develop more targeted therapy for these conditions. Heritability of allergic disease Heritability is the proportion of observed variation in a particular trait that can be attributed to inherited genetic factors in contrast to environmental ones. 00005-6 33 2 The genetic basis of allergy and asthma a number of reasons, including common environmental exposure and biased ascertainment, as well as having a true genetic disposition.
23 1 Introduction to mechanisms of allergic disease β Ligand binding site The immunoglobulin superfamily of endothelial cell expressed adhesion molecules α Divalent cation binding sites Divalent cation binding sites NH2 Cysteine-rich repeats NH2 S S Membrane COOH Transmembrane domain COOH Cytoplasmic domains Fig. 27 The structure of an integrin heterodimer with its α and β subunits. Examples of integrin heterodimers include: β1 integrins (α4β1 or VLA-4), β2 integrins (αLβ2 or LFA-1), and β7 integrins (α4β7).
Biology of lung dendritic cells at the origin of asthma. Immunity 2009; 31:412–424. Lloyd CM, Hawrylowicz CM. Regulatory T cells in asthma. Immunity 2009; 31:438–449. Medoff BD, Thomase SY, Luster AD. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol 2008; 26:205–232. Ochs HD, Oukka M, Torgerson TR. TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol 2009; 123:977–983. Paul WE, Zhu J. How are TH2-type immune responses initiated and amplified?
Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)